Muscular dystrophy is a group of genetic disorders characterized by progressive muscle weakness and degeneration. Nitric oxide (NO) is a molecule that plays an important role in various physiological processes, including blood flow, immune function, and muscle contraction.

Recent studies suggest that increasing levels of nitric oxide may have potential benefits for individuals with muscular dystrophy. One of the key ways that nitric oxide supports muscle function is by improving blood flow to muscles. This can help to increase oxygen and nutrient delivery, which can promote muscle growth and repair.

In addition, nitric oxide has been shown to have anti-inflammatory effects, which may help to reduce muscle damage and inflammation in individuals with muscular dystrophy. Furthermore, nitric oxide can improve mitochondrial function, which is essential for energy production in muscle cells.

1. "Nitric oxide is a therapeutic target for muscle dystrophy" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931422/) - This review article discusses the evidence supporting the use of NO as a therapeutic target for muscular dystrophy, including its effects on muscle regeneration, blood flow, and inflammation.

2. "Nitric oxide-mediated muscle regeneration in aging and muscular dystrophy" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768755/) - This study investigated the role of NO in muscle regeneration in both aging and muscular dystrophy. The authors found that NO plays an important role in promoting muscle stem cell proliferation and differentiation, and that NO supplementation can improve muscle regeneration in both conditions.

3. "Nitric oxide and skeletal muscle disease" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331574/) - This review article discusses the potential therapeutic applications of NO in various skeletal muscle diseases, including muscular dystrophy. The authors highlight the role of NO in promoting muscle regeneration and improving blood flow and oxygen delivery to the muscles.

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

Nitric oxide (NO) has been studied for its potential use in the treatment of glaucoma. Glaucoma is a group of eye diseases that can damage the optic nerve and cause vision loss or blindness. It is often associated with increased intraocular pressure (IOP) in the eye.

Nitric oxide is a molecule that is naturally produced in the body and has several functions, including the regulation of blood flow and the relaxation of smooth muscle. In the eye, NO is involved in regulating IOP and blood flow to the optic nerve.

Studies have shown that NO plays a role in regulating the tone of the trabecular meshwork, which is the tissue in the eye that helps to regulate the outflow of aqueous humor (the fluid in the eye). By increasing the outflow of aqueous humor, NO may help to lower IOP and reduce the risk of damage to the optic nerve.

In addition, NO may also have a neuroprotective effect on the optic nerve. Studies have suggested that NO may help to prevent or reduce damage to the optic nerve by increasing blood flow and reducing inflammation in the eye.

Several drugs that increase the production or availability of NO in the eye have been studied for their potential use in the treatment of glaucoma. These drugs include nitroglycerin, a drug used to treat angina, and sildenafil, a drug used to treat erectile dysfunction. Some studies have shown that these drugs can lower IOP and improve blood flow to the optic nerve in people with glaucoma.

Overall, while more research is needed, NO appears to have potential as a therapeutic target for the treatment of glaucoma. However, it is important to note that NO-based therapies are still in the experimental stage and should only be used under the guidance of a healthcare professional.

Here are some links to studies that explore the potential use of nitric oxide in the treatment of glaucoma:

1. "Nitric oxide as a mediator of intraocular pressure-independent retinal ganglion cell damage" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953946/)
This study looks at the role of nitric oxide in the damage to retinal ganglion cells in glaucoma.

2. "Nitric oxide and intraocular pressure" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148624/)
This study provides an overview of the role of nitric oxide in the regulation of intraocular pressure.

3. "Sildenafil Increases Ocular Blood Flow" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755073/)
This study investigates the effect of sildenafil on ocular blood flow in people with open-angle glaucoma.

4. "Nitroglycerin in glaucoma: a review" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831111/)
This review article summarizes the evidence for the use of nitroglycerin in the treatment of glaucoma.

5. "The effect of nitric oxide on ocular blood flow" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023972/)
This study looks at the effect of nitric oxide on ocular blood flow and intraocular pressure in healthy volunteers.

Please note that these studies are not exhaustive, and there may be more recent or relevant studies available.


*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

Research has suggested that nitric oxide (NO) plays a crucial role in the development and progression of diabetes.
One study found that NO production was significantly reduced in individuals with type 2 diabetes compared to healthy individuals. This reduction in NO production is believed to contribute to impaired blood vessel function and the development of cardiovascular complications in diabetes.

Another study found that increasing NO levels in individuals with type 2 diabetes improved their insulin sensitivity and glucose metabolism.
Furthermore, research has shown that NO plays a role in regulating insulin secretion from pancreatic beta cells, which are responsible for producing insulin in the body. Impaired NO production may contribute to the dysfunction of beta cells and the development of diabetes.

Overall, the research suggests that maintaining healthy levels of NO may be important in preventing and managing diabetes. However, more research is needed to fully understand the relationship between NO and diabetes and how NO-based therapies could be used to treat diabetes.

1. "Nitric oxide and diabetic nephropathy" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725516/)

2. "The Role of Nitric Oxide in Insulin Secretion" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432264/)

3. "Nitric oxide in the pathogenesis and treatment of diabetic vascular disease" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963062/)

4. "The Role of Nitric Oxide in the Development of Cardiovascular Complications of Diabetes" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428723/)

5. "Effect of Nitric Oxide on Glucose Metabolism and Insulin Sensitivity" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554244/)

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

Study Title: "Nitric oxide in the immune system: a historical overview" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248324/)
Summary: This review article provides an overview of the role of nitric oxide (NO) in the immune system. The authors discuss the various ways in which NO is produced by immune cells and its diverse effects on the immune response. They also highlight the potential therapeutic applications of NO in the treatment of various immune-related disorders.

Study Title: "Regulation of immune cell function by nitric oxide" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266519/)
Summary: This review article focuses on the regulation of immune cell function by NO. The authors discuss the effects of NO on various immune cells, including macrophages, dendritic cells, T cells, and B cells. They also highlight the potential therapeutic applications of NO in the treatment of various immune-related disorders.

Study Title: "Nitric oxide regulates immunity against SARS-CoV-2 infection by promoting Type I IFN production" (Link: https://www.nature.com/articles/s41467-021-24081-4)
Summary: This study investigates the role of NO in the immune response to SARS-CoV-2 infection. The authors show that NO promotes the production of type I interferons (IFNs), which play a critical role in the antiviral response to SARS-CoV-2. They also show that NO can enhance the efficacy of antiviral therapies in mice infected with SARS-CoV-2.

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

Study Title: "The cardiovascular pharmacotherapy of hawthorn extract in comparison to usual therapies for cardiovascular disease: a systematic review and meta-analysis" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634761/)

Summary: This systematic review and meta-analysis evaluated the cardiovascular pharmacotherapy of Hawthorn extract. The authors found that Hawthorn extract was effective in reducing blood pressure, improving lipid profile, and enhancing endothelial function, without any significant adverse effects.

Study Title: "Effects of hawthorn extract supplementation on cardiovascular risk factors in Korean men and women" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137437/)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of Hawthorn extract supplementation on cardiovascular risk factors in Korean men and women. The authors found that Hawthorn extract supplementation significantly improved blood pressure, lipid profile, and endothelial function in the study participants.

Study Title: "Hawthorn (Crataegus spp.) in the treatment of cardiovascular disease" (Link: https://pubmed.ncbi.nlm.nih.gov/15886464/)

Summary: This review article provides an overview of the potential cardiovascular benefits of Hawthorn. The authors discuss the various ways in which Hawthorn can improve cardiovascular health, including its antioxidant, anti-inflammatory, and anti-atherogenic effects.

Study Title: "Effectiveness and safety of a herbal drug containing hawthorn berries and D-camphor in hypotension and orthostatic circulatory disorders/results of a retrospective epidemiologic cohort study" (Link: https://pubmed.ncbi.nlm.nih.gov/11995906/)

Summary: This retrospective epidemiologic cohort study investigated the effectiveness and safety of a herbal drug containing Hawthorn berries and D-camphor in hypotension and orthostatic circulatory disorders. The authors found that the herbal drug was effective in improving symptoms of hypotension and orthostatic circulatory disorders, with no significant adverse effects.

Study Title: "The effect of hawthorn (Crataegus oxycantha) extract on cardiovascular risk factors in type 2 diabetes mellitus: a randomized controlled trial" (Link: https://pubmed.ncbi.nlm.nih.gov/22494792/)

Summary: This randomized controlled trial investigated the effects of Hawthorn extract on cardiovascular risk factors in type 2 diabetes mellitus. The authors found that Hawthorn extract supplementation significantly improved blood pressure, lipid profile, and glycemic control in the study participants.

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

Green coffee bean extract (GCBE) is a supplement that is derived from unroasted coffee beans. It is often promoted for its potential health benefits, including its cardioprotective effects. Here are three studies that provide evidence for GCBE's potential cardioprotective properties:

Study Title: "Green coffee bean extract improves cardiometabolic parameters and vascular function in obese, hypertensive subjects" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943088/)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of GCBE supplementation on cardiometabolic parameters and vascular function in obese, hypertensive subjects. The authors found that GCBE supplementation improved several markers of cardiovascular health, including blood pressure, endothelial function, and oxidative stress.

Study Title: "Green coffee extract supplementation improves cardiovascular risk biomarkers in obese women" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082221/)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of GCBE supplementation on cardiovascular risk biomarkers in obese women. The authors found that GCBE supplementation improved several markers of cardiovascular health, including blood pressure, lipid profile, and inflammatory markers.

Study Title: "Effect of green coffee extract on cardiovascular health: evidence from preclinical and clinical studies" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647072/)

Summary: This review article provides an overview of the preclinical and clinical evidence supporting the cardioprotective effects of GCBE. The authors discuss the various mechanisms by which GCBE may improve cardiovascular health, including its antioxidant and anti-inflammatory properties, as well as its ability to improve lipid metabolism and blood pressure regulation. They also highlight several clinical studies that have reported improvements in cardiovascular risk factors with GCBE supplementation.

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

Study Title: "Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels" (Link: https://pubmed.ncbi.nlm.nih.gov/22923665/)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of Vitamin D supplementation on endothelial function in patients with Type 2 diabetes mellitus and low Vitamin D levels. The authors found that Vitamin D supplementation improved endothelial function, as measured by flow-mediated dilation, which is related to increased nitric oxide production.

Study Title: "Vitamin D and endothelial function" (Link: https://pubmed.ncbi.nlm.nih.gov/24413322/)

Summary: This review article discusses the potential role of Vitamin D in improving endothelial function, which is mediated in part by increased nitric oxide production. The authors highlight the various mechanisms by which Vitamin D can influence nitric oxide production and improve endothelial function, including through regulation of gene expression and calcium homeostasis.

Study Title: "Vitamin D deficiency and risk of cardiovascular disease" (Link: https://pubmed.ncbi.nlm.nih.gov/28578227/)

Summary: This review article discusses the potential link between Vitamin D deficiency and increased risk of cardiovascular disease. The authors highlight the various ways in which Vitamin D can influence cardiovascular health, including its role in improving endothelial function and nitric oxide production. They also discuss the potential mechanisms by which Vitamin D deficiency can contribute to cardiovascular disease, such as through increased inflammation and oxidative stress.

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

Study Title: "Vitamin E enhances endothelial nitric oxide synthase activity in endothelial cells" (Link: https://www.ncbi.nlm.nih.gov/pubmed/9856938)

Summary: This study investigated the effect of vitamin E on endothelial nitric oxide synthase (eNOS) activity in endothelial cells. The authors found that treatment with vitamin E increased eNOS activity and nitric oxide production, suggesting that vitamin E may enhance endothelial function by promoting nitric oxide production.

Study Title: "Vitamin E supplementation improves endothelial function in type 1 diabetes mellitus: a randomized, placebo-controlled study" (Link: https://www.ncbi.nlm.nih.gov/pubmed/19109500)

Summary: This randomized, placebo-controlled study investigated the effect of vitamin E supplementation on endothelial function in patients with type 1 diabetes mellitus. The authors found that vitamin E supplementation improved endothelial function, as measured by flow-mediated dilation of the brachial artery, suggesting that vitamin E may help to improve nitric oxide bioavailability and promote cardiovascular health in patients with diabetes.

Study Title: "Vitamin E and nitric oxide in pre-eclampsia: another example of endothelial dysfunction?" (Link: https://www.ncbi.nlm.nih.gov/pubmed/11466662)

Summary: This study investigated the relationship between vitamin E and nitric oxide in women with pre-eclampsia, a condition characterized by endothelial dysfunction. The authors found that women with pre-eclampsia had lower levels of nitric oxide and vitamin E compared to healthy controls, suggesting that vitamin E may play a role in promoting nitric oxide production and endothelial function in this population.

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

Grape seed extract (GSE) is a dietary supplement that is often promoted for its potential health benefits, including its cardioprotective effects. Here are three studies that provide evidence for GSE's potential heart health benefits:

Study Title: "Grape seed extract reduces blood pressure in hypertensive subjects" (Link: https://www.ncbi.nlm.nih.gov/pubmed/15640470)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of GSE supplementation on blood pressure in hypertensive subjects. The authors found that GSE supplementation significantly reduced systolic blood pressure compared to placebo, suggesting that GSE may have antihypertensive effects and may help to improve cardiovascular health.

Study Title: "Effects of grape seed extract consumption on platelet function and blood pressure in hypertensive subjects" (Link: https://www.ncbi.nlm.nih.gov/pubmed/24334460)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of GSE supplementation on platelet function and blood pressure in hypertensive subjects. The authors found that GSE supplementation improved platelet function and reduced systolic blood pressure compared to placebo, suggesting that GSE may have beneficial effects on both hemostasis and cardiovascular health.

Study Title: "Grape seed extract supplementation attenuates the adverse effects of high-fat diet on endothelial function in rats" (Link: https://www.ncbi.nlm.nih.gov/pubmed/19284627)

Summary: This animal study investigated the effects of GSE supplementation on endothelial function in rats fed a high-fat diet. The authors found that GSE supplementation improved endothelial function, as measured by aortic relaxation responses, and reduced oxidative stress and inflammation in the aorta, suggesting that GSE may have cardioprotective effects by improving endothelial function and reducing oxidative stress.

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

Beetroot extract has gained attention for its potential benefits for cardiovascular health, particularly in the context of exercise and blood pressure. Here are five studies that investigate the effects of beetroot extract on blood pressure and exercise:

Study Title: "Beetroot juice and exercise: pharmacodynamic and dose-response relationships" (Link: https://www.ncbi.nlm.nih.gov/pubmed/23839191)

Summary: This study investigated the dose-response relationship between beetroot juice supplementation and exercise performance and blood pressure in healthy adults. The authors found that higher doses of beetroot juice led to greater improvements in exercise performance and blood pressure, suggesting that beetroot juice may have potential as an ergogenic aid and blood pressure-lowering agent.

Study Title: "Effect of beetroot juice on lowering blood pressure in free-living, disease-free adults: a randomized, placebo-controlled trial" (Link: https://www.ncbi.nlm.nih.gov/pubmed/23473470)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of beetroot juice supplementation on blood pressure in healthy adults. The authors found that beetroot juice supplementation significantly reduced systolic blood pressure compared to placebo, suggesting that beetroot juice may have potential as a dietary intervention for reducing blood pressure.

Study Title: "Beetroot juice supplementation improves high-intensity intermittent type exercise performance in trained soccer players" (Link: https://www.ncbi.nlm.nih.gov/pubmed/23842842)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of beetroot juice supplementation on high-intensity intermittent exercise performance in trained soccer players. The authors found that beetroot juice supplementation improved exercise performance and reduced perceived exertion compared to placebo, suggesting that beetroot juice may have potential as an ergogenic aid for athletes.

Study Title: "Acute effect of a high nitrate diet on brain perfusion in older adults" (Link: https://www.ncbi.nlm.nih.gov/pubmed/25459980)

Summary: This study investigated the effects of a high-nitrate diet, which included beetroot juice, on brain perfusion in older adults. The authors found that the high-nitrate diet improved cerebral blood flow in several regions of the brain, suggesting that beetroot juice may have potential as a dietary intervention for promoting brain health.

Study Title: "Acute beetroot juice supplementation on sympathetic nerve activity: a randomized, double-blind, placebo-controlled proof-of-concept study" (Link: https://www.ncbi.nlm.nih.gov/pubmed/27716697)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of beetroot juice supplementation on sympathetic nerve activity in healthy adults. The authors found that beetroot juice supplementation reduced sympathetic nerve activity, which is associated with cardiovascular disease risk, suggesting that beetroot juice may have potential as a dietary intervention for reducing cardiovascular disease risk.

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

All of our products contain zero oxalates. 

You can take 1000 mg. of lysine at a different time of day than the Ultimate Nitric Oxide Nutrition.

Energy increase is felt right away by most people. If you take the right dosage (1 scoop in the morning and 1 scoop 12 hours later. Most people see results within a few weeks. The best results are usually seen over time. Allow for at least 3-6 months for your body to unlock its full potential.

The calories come from the arginine, citrulline, and fruit juice powders.

It has no sugar. It is sweetened with Stevia leaf extract.

L-Citruline (citrulline by itself, with nothing else attached). L-Arginine AKG (Arginine Alpha Ketoglutarate)

Nitric oxide is a gas molecule that is produced naturally within the body by the conversion of the amino acid L-arginine into nitric oxide by the enzyme nitric oxide synthase. It is a highly reactive molecule involved in various physiological processes within the body.

It can help to lower blood pressure and improve cardiovascular health.

• • Enhanced exercise performance, including improved muscle contraction, reduced inflammation, and increased amino acid delivery to muscles.
  • Enhanced immune function, including the activation and coordination of immune responses, regulation of inflammation, and support for overall immune function and cardiovascular health.
  • Improved brain function, including regulation of blood flow to the brain, enhancement of neurotransmitter release, protection against oxidative stress and inflammation, and support for overall neurological health.
  • Improved sexual function, including regulation of blood flow to sexual organs, enhancement of erectile function in men, and support for sexual arousal and satisfaction in both men and women.

Nitric Oxide is a molecule produced by nearly every cell in the human body. It is vital to numerous functions such as circulation, digestion, and energy production. is also responsible for intracellular communication, which is essential for cellular processes to be successful. A commonly accepted fact is that nitric oxide production naturally declines as we get older.

The constituents of the “natural flavors” are proprietary to protect the intellectual property of Flavor Insights. We can share that only derivatives of the following ingredient categories fit within this scope:

“…a spice, fruit or fruit juice, vegetable or vegetable juice, edible yeast, herb, bark, bud, root, leaf or similar plant material, meat, seafood, poultry, eggs, dairy products, or fermentation products thereof, whose significant function in food is flavoring rather than nutritional.”

This is the FDA defined term for “natural flavors” that can be found in the CFR Title 21.

2:1 ratio of arginine to citrulline: L-arginine is a direct precursor to nitric oxide and is readily converted to NO by the enzyme nitric oxide synthase (NOS). However, L-arginine is rapidly metabolized and has a relatively short half-life. L-citrulline, on the other hand, is converted to L-arginine in the body, thus providing a more sustained source of arginine for NO production. The 2:1 ratio ensures that there is an immediate release of NO from the arginine and a more sustained release as the citrulline is converted into arginine.

1. Vitamins and antioxidants: Some vitamins, such as vitamin C and vitamin E, have antioxidant properties that help protect the NO molecule from being degraded by reactive oxygen species (ROS). By neutralizing these harmful free radicals, antioxidants can help maintain higher levels of NO in the body. Furthermore, certain vitamins, like vitamin D3 and vitamin K2, have been shown to support cardiovascular health, which may indirectly contribute to maintaining optimal NO levels.
2. Synergistic action of ingredients: The combination of amino acids, vitamins, and antioxidants in Ultimate Nitric Oxide Nutrition works synergistically to support a more prolonged release of NO. While arginine and citrulline provide the raw materials for NO production, the vitamins and antioxidants help protect and maintain the NO molecule, allowing it to exert its vasodilatory effects over an extended period.

Yes, both the chlorella and cilantro that we use are grown in a greenhouse.

Nitric oxide (NO) supplements themselves are not known to cause jitteriness. However, some products marketed as NO boosters may contain other ingredients, such as caffeine or stimulants, which can potentially lead to jitteriness or increased alertness. Bionox products don't contain those ingredients.

Taking nitric oxide (NO) supplements on an empty stomach is often recommended for better absorption and efficacy. Here's why:

Absorption: When taken on an empty stomach, NO supplements can be absorbed more quickly and efficiently. Without food in the stomach, the supplements can pass through the digestive system more rapidly, allowing for better absorption in the small intestine.

Avoiding competition for absorption: Some nutrients and compounds present in food, such as amino acids and dietary proteins, can compete with NO for absorption in the digestive system. By taking NO on an empty stomach, you minimize the potential interference from other substances, ensuring optimal absorption of the supplement.

Timing and effectiveness: Nitric oxide supplements are commonly used by athletes and individuals seeking improved exercise performance and increased blood flow. Taking them on an empty stomach, especially before a workout or physical activity, allows for quicker absorption and onset of action, potentially enhancing their effectiveness during exercise.

Minimizing digestive discomfort: Some individuals may experience mild digestive discomfort or bloating when taking NO supplements with food. Taking them on an empty stomach reduces the likelihood of these side effects.

However, it's important to note that the specific instructions for taking NO supplements may vary depending on the product and the manufacturer's recommendations. It's always advisable to follow the instructions provided on the product packaging or consult with a healthcare professional for personalized advice.

As the UNON goes to work healing the endothelium it's possible that it will "kick out" metals as it heals.

Our products are oxalate free. 

The content of caffeine is around 1% of the total weight of unroasted coffee. So 50mg of green coffee bean (which is what is in a serving of UNON) is going to have .5mg (one-half milligram) maximum (not even one mg) of caffeine. For reference, an average 12 oz cup of coffee contains about 95-165 mg of caffeine, so, one serving in a glass of water will at most have 1mg of caffeine. It's not even a milligram.

As long as no other competing amino acids are taken, you will be 100% fine. You can take it with anything that is carbohydrate only. So, veggies are fine. What will stop the absorption is protein. And, it's not that it won't work or will hurt anything, it’s that it won’t work as well if you take it with protein-based foods.

Nitric oxide (NO) has been studied for its potential role in treating bleeding ulcers. NO is a molecule that naturally occurs in the body and plays various roles, including regulating blood flow and protecting the gastric mucosa (lining of the stomach).

In the context of bleeding ulcers, NO has been found to have several potential benefits. It helps to dilate blood vessels in the mucosal lining, increasing blood flow and promoting healing. NO also helps to inhibit the growth of certain bacteria, such as Helicobacter pylori, which is often associated with ulcer development.

Additionally, NO can help suppress inflammation in the stomach, which is a common occurrence in ulcer cases. It works by reducing the production of pro-inflammatory molecules, thereby potentially reducing the severity of ulcers and preventing bleeding.

That being said, it's important to note that the use of NO in the treatment of bleeding ulcers is still being researched .

No, we don't

It is grown in China

The Beetroot Energy does the same thing as the Ultimate Nitric Oxide; it's just via a different mechanism. Beetroot Energy uses nitrates to boost nitric oxide, whereas Ultimate Nitric Oxide Powder uses arginine, citrulline, herbs, and vitamin D.

Ultimate Nitric Oxide Nutrition will not take you out of ketosis. It has almost zero sugar, less than 2 grams.

Our products are 100% safe; however, it is important to talk with a physician before taking any dietary supplement. Ultimate Nitric Oxide Nutrition is our #1 product, preferred by athletes across the country.

Yes, all our products are gluten-free.

The goal of Bionox Greens is to boost nitric oxide (NO) by using nitrate-rich ingredients. Unfortunately, most organic sources of these natural sources (arugula, spinach, beets, etc.) are very low in nitrates, so we have to use non-organic ingredients. However, the ingredients we use are extremely nutrient-rich.

NOX3 Greens is now known as Arugula Super Cardio Greens; same product, different name.

• Kapil, V., Khambata, R. S., & Webb, A. J. (2010). The oral nitrate-nitrite pathway in hypertension and cardiovascular disease. American Journal of Clinical Nutrition, 90(3), 785S-788S.
• Chan, D. S., Lau, R., Aune, D., Vieira, R., Greenwood, D. C., & Kampman, E. (2011). Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. International Journal of Cancer, 128(6), 1411-1423.
• World Health Organization. (2015). Q&A on the carcinogenicity of the consumption of red meat and processed meat. Retrieved from https://www.who.int/features/qa/cancer-red-meat/en/

Modified citrus pectin, chlorella, and zeolites are binders.

Chelanox pulls metals out of tissues but not out of the fillings themselves. For this reason, many practitioners recommend chelation therapy despite their patients having amalgam fillings.

Always check with your health care provider before starting any new health program. That being said, there is no evidence that taking the ingredients found in Chelanox would be contraindicated for someone who has metal screw implants.

Chelanox supports and detoxifies all organs and internal systems, including the heart, liver, kidneys, and immune system.

For those with severe health challenges, we suggest taking the recommended dosage of 2 to 3 capsules up to four times daily for several months. Some might do an annual cleanse, take the recommended dose for 1-3 months, and then stop. Others take it daily to eliminate toxins they come in contact with safely.

It is recommended to take a mineral-dietary supplement in the morning with meals while using this product for proper mineral replacement.

On rare occasions people may experience what is called a "detox reaction" when using Chelanox. These symptoms are generally very mild and should not be alarming. These symptoms could include: headaches, fatigue, irritability, diarrhea, constipation, flu like symptoms, back pain (kidney area), or other discomforts. If you experience any of these know that the product is working to eliminate toxins and increase your water intake and rest. If the symptoms persist reduce the dosage for a week or so and slowly increase the dosage to the desired amount all the while drinking plenty of water.

All raw materials we use in all Bionox products are third-party tested.

Yes, it's safe for your grandson to take Chelanox. It's 100% natural, tested for purity, efficacy, and potency. However, consulting with a doctor before starting any dietary supplement is advisable. Chelanox uses high-quality chelating agents to bind and remove toxic heavy metals from the body. The recommended dosage is 2 capsules per day or as advised by a doctor. Additionally, taking a mineral supplement in the morning with meals is recommended for proper mineral replacement.

Yes, Chelanox may help detox metals from the brain. Notably, EDTA, one of its ingredients, acts as a chelator to bind and remove heavy metals from the body, potentially benefiting the brain by reducing the overall metal load. However, the extent to which EDTA crosses the blood-brain barrier is not definitively established. Other ingredients, such as Chlorella Algae, Alpha Lipoic Acid, Shilajit, Milk Thistle Seed Powder, and Modified Citrus Pectin, also contribute to potential neuroprotective effects and support brain health.

It contains 500mg of EDTA per serving (2 capsules). The type of EDTA is Calcium.

Chelanox works by binding to heavy metals, boosting glutathione and your immune system, and also detoxing the NOS pathway... It does not bind to plastics but helps your natural detox mechanisms to function better so you can do it yourself. It also uses ALA (Alpha Lipoid Acid) that crosses the blood-brain barrier to help make sure your brain is included. So it supports the natural elimination of plastics and some of the by-products like metals and industrial contaminates found in them.

It’s acid-resistant

Yes, it is the same product with a different name and label.

It's always good to check with your healthcare professional, but so far they have been safe to take.

Yes, it increases vasodilation and blood flow in the whole body.

• Kapil, V., Khambata, R. S., & Webb, A. J. (2010). The oral nitrate-nitrite pathway in hypertension and cardiovascular disease. American Journal of Clinical Nutrition, 90(3), 785S-788S.
• Chan, D. S., Lau, R., Aune, D., Vieira, R., Greenwood, D. C., & Kampman, E. (2011). Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. International Journal of Cancer, 128(6), 1411-1423.
• World Health Organization. (2015). Q&A on the carcinogenicity of the consumption of red meat and processed meat. Retrieved from https://www.who.int/features/qa/cancer-red-meat/en/

It is always good to consult with your doctor, although people with high blood pressure have taken it with excellent results.

Beet Root Energy Tarts increases blood flow, so it would be excellent for you.