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Nitric Oxide Studies & FAQ's

Why is nitric oxide so important?

Nitric oxide is essential since it allows blood, nutrients, and oxygen to travel to every part of your body. As we get older, our bodies' natural ability to make nitric oxide reduces, which increases the chances of unwanted health complications. By taking Bionox supplements, we can increase circulation, energy levels, digestion, muscle recovery, bones, sex, athletics, vitality, vision, and brain function.

Why do I need to be watching my nitric oxide levels?

As you get older, your body's ability to make nitric oxide decreases, opening you up to the risk of health challenges. By taking Bionox supplements, you are activating the innate power of your body to realize optimum health.

Is there really a need for a supplement?

Nitric Oxide supplements are overall safe to take. Each Bionox product serves a different purpose to help your body achieve optimum health..

What if I experience any negative symptoms?

All Bionox products are considered GRAS (Generally Regarded As Safe) compliant. However, as you use therapeutic doses of any nutrition, you may experience symptoms like digestive upset, fatigue, or others. Every person is unique and should be treated as such. Our general recommendation if you experience any unwanted effects based on perceived use of our products is to stop taking them for a few days and then try again slowly; such as taking half of the recommended dose or less and working up to the full dose if possible. If you still experience unwanted symptoms, you are welcome to get a full refund for your purchase.

Are there studies on nitric oxide and muscular dystrohpy?

Muscular dystrophy is a group of genetic disorders characterized by progressive muscle weakness and degeneration. Nitric oxide (NO) is a molecule that plays an important role in various physiological processes, including blood flow, immune function, and muscle contraction.

Recent studies suggest that increasing levels of nitric oxide may have potential benefits for individuals with muscular dystrophy. One of the key ways that nitric oxide supports muscle function is by improving blood flow to muscles. This can help to increase oxygen and nutrient delivery, which can promote muscle growth and repair.

In addition, nitric oxide has been shown to have anti-inflammatory effects, which may help to reduce muscle damage and inflammation in individuals with muscular dystrophy. Furthermore, nitric oxide can improve mitochondrial function, which is essential for energy production in muscle cells.

1. "Nitric oxide is a therapeutic target for muscle dystrophy" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931422/) - This review article discusses the evidence supporting the use of NO as a therapeutic target for muscular dystrophy, including its effects on muscle regeneration, blood flow, and inflammation.

2. "Nitric oxide-mediated muscle regeneration in aging and muscular dystrophy" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768755/) - This study investigated the role of NO in muscle regeneration in both aging and muscular dystrophy. The authors found that NO plays an important role in promoting muscle stem cell proliferation and differentiation, and that NO supplementation can improve muscle regeneration in both conditions.

3. "Nitric oxide and skeletal muscle disease" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331574/) - This review article discusses the potential therapeutic applications of NO in various skeletal muscle diseases, including muscular dystrophy. The authors highlight the role of NO in promoting muscle regeneration and improving blood flow and oxygen delivery to the muscles.

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

Are there studies on nitric oxide and glaucoma?

Nitric oxide (NO) has been studied for its potential use in the treatment of glaucoma. Glaucoma is a group of eye diseases that can damage the optic nerve and cause vision loss or blindness. It is often associated with increased intraocular pressure (IOP) in the eye.

Nitric oxide is a molecule that is naturally produced in the body and has several functions, including the regulation of blood flow and the relaxation of smooth muscle. In the eye, NO is involved in regulating IOP and blood flow to the optic nerve.

Studies have shown that NO plays a role in regulating the tone of the trabecular meshwork, which is the tissue in the eye that helps to regulate the outflow of aqueous humor (the fluid in the eye). By increasing the outflow of aqueous humor, NO may help to lower IOP and reduce the risk of damage to the optic nerve.

In addition, NO may also have a neuroprotective effect on the optic nerve. Studies have suggested that NO may help to prevent or reduce damage to the optic nerve by increasing blood flow and reducing inflammation in the eye.

Several drugs that increase the production or availability of NO in the eye have been studied for their potential use in the treatment of glaucoma. These drugs include nitroglycerin, a drug used to treat angina, and sildenafil, a drug used to treat erectile dysfunction. Some studies have shown that these drugs can lower IOP and improve blood flow to the optic nerve in people with glaucoma.

Overall, while more research is needed, NO appears to have potential as a therapeutic target for the treatment of glaucoma. However, it is important to note that NO-based therapies are still in the experimental stage and should only be used under the guidance of a healthcare professional.

Here are some links to studies that explore the potential use of nitric oxide in the treatment of glaucoma:

1. "Nitric oxide as a mediator of intraocular pressure-independent retinal ganglion cell damage" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953946/)
This study looks at the role of nitric oxide in the damage to retinal ganglion cells in glaucoma.

2. "Nitric oxide and intraocular pressure" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148624/)
This study provides an overview of the role of nitric oxide in the regulation of intraocular pressure.

3. "Sildenafil Increases Ocular Blood Flow" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755073/)
This study investigates the effect of sildenafil on ocular blood flow in people with open-angle glaucoma.

4. "Nitroglycerin in glaucoma: a review" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831111/)
This review article summarizes the evidence for the use of nitroglycerin in the treatment of glaucoma.

5. "The effect of nitric oxide on ocular blood flow" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023972/)
This study looks at the effect of nitric oxide on ocular blood flow and intraocular pressure in healthy volunteers.

Please note that these studies are not exhaustive, and there may be more recent or relevant studies available.


*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

What does the research say about nitric oxide and diabetes?

Research has suggested that nitric oxide (NO) plays a crucial role in the development and progression of diabetes.
One study found that NO production was significantly reduced in individuals with type 2 diabetes compared to healthy individuals. This reduction in NO production is believed to contribute to impaired blood vessel function and the development of cardiovascular complications in diabetes.

Another study found that increasing NO levels in individuals with type 2 diabetes improved their insulin sensitivity and glucose metabolism.
Furthermore, research has shown that NO plays a role in regulating insulin secretion from pancreatic beta cells, which are responsible for producing insulin in the body. Impaired NO production may contribute to the dysfunction of beta cells and the development of diabetes.

Overall, the research suggests that maintaining healthy levels of NO may be important in preventing and managing diabetes. However, more research is needed to fully understand the relationship between NO and diabetes and how NO-based therapies could be used to treat diabetes.

1. "Nitric oxide and diabetic nephropathy" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725516/)

2. "The Role of Nitric Oxide in Insulin Secretion" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432264/)

3. "Nitric oxide in the pathogenesis and treatment of diabetic vascular disease" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963062/)

4. "The Role of Nitric Oxide in the Development of Cardiovascular Complications of Diabetes" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428723/)

5. "Effect of Nitric Oxide on Glucose Metabolism and Insulin Sensitivity" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554244/)

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

Are there studies on nitric oxide and the immune system?

Study Title: "Nitric oxide in the immune system: a historical overview" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248324/)
Summary: This review article provides an overview of the role of nitric oxide (NO) in the immune system. The authors discuss the various ways in which NO is produced by immune cells and its diverse effects on the immune response. They also highlight the potential therapeutic applications of NO in the treatment of various immune-related disorders.

Study Title: "Regulation of immune cell function by nitric oxide" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266519/)
Summary: This review article focuses on the regulation of immune cell function by NO. The authors discuss the effects of NO on various immune cells, including macrophages, dendritic cells, T cells, and B cells. They also highlight the potential therapeutic applications of NO in the treatment of various immune-related disorders.

Study Title: "Nitric oxide regulates immunity against SARS-CoV-2 infection by promoting Type I IFN production" (Link: https://www.nature.com/articles/s41467-021-24081-4)
Summary: This study investigates the role of NO in the immune response to SARS-CoV-2 infection. The authors show that NO promotes the production of type I interferons (IFNs), which play a critical role in the antiviral response to SARS-CoV-2. They also show that NO can enhance the efficacy of antiviral therapies in mice infected with SARS-CoV-2.

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.


What do studies say about l-arginine supplementation?

Study Title: "L-arginine and Cardiovascular Diseases: From Molecular Mechanisms to Therapeutic Implications" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360456/)

Summary: This review article discusses the molecular mechanisms by which L-arginine supplementation may benefit cardiovascular health. The authors highlight the potential role of L-arginine in improving endothelial function, reducing inflammation, and lowering blood pressure.

 

Study Title: "L-arginine and heart failure" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842162/)

Summary: This review article discusses the potential benefits of L-arginine supplementation in patients with heart failure. The authors highlight the potential role of L-arginine in improving endothelial function, reducing inflammation, and enhancing exercise capacity.

 

Study Title: "Effects of L-arginine supplementation on blood pressure: a meta-analysis of randomized controlled trials" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573572/)

Summary: This meta-analysis of randomized controlled trials evaluates the effects of L-arginine supplementation on blood pressure. The authors found that L-arginine supplementation significantly reduced both systolic and diastolic blood pressure.

 

Study Title: "Effects of long-term oral L-arginine on the nitric oxide synthase pathway in the urine from patients with coronary artery disease" (Link: https://pubmed.ncbi.nlm.nih.gov/22227316/)

Summary: This study investigates the effects of long-term L-arginine supplementation on the nitric oxide synthase pathway in patients with coronary artery disease. The authors found that L-arginine supplementation increased nitric oxide production and improved endothelial function in these patients.

 

Study Title: "L-Arginine in the management of cardiovascular diseases" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753343/)

Summary: This review article discusses the potential benefits of L-arginine supplementation in the management of cardiovascular diseases, including hypertension, heart failure, and atherosclerosis. The authors highlight the potential role of L-arginine in improving endothelial function, reducing oxidative stress, and enhancing nitric oxide production.

 
 
*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

What do studies on hawthorn berry say?

Study Title: "The cardiovascular pharmacotherapy of hawthorn extract in comparison to usual therapies for cardiovascular disease: a systematic review and meta-analysis" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634761/)

Summary: This systematic review and meta-analysis evaluated the cardiovascular pharmacotherapy of Hawthorn extract. The authors found that Hawthorn extract was effective in reducing blood pressure, improving lipid profile, and enhancing endothelial function, without any significant adverse effects.

 

Study Title: "Effects of hawthorn extract supplementation on cardiovascular risk factors in Korean men and women" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137437/)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of Hawthorn extract supplementation on cardiovascular risk factors in Korean men and women. The authors found that Hawthorn extract supplementation significantly improved blood pressure, lipid profile, and endothelial function in the study participants.

 

Study Title: "Hawthorn (Crataegus spp.) in the treatment of cardiovascular disease" (Link: https://pubmed.ncbi.nlm.nih.gov/15886464/)

Summary: This review article provides an overview of the potential cardiovascular benefits of Hawthorn. The authors discuss the various ways in which Hawthorn can improve cardiovascular health, including its antioxidant, anti-inflammatory, and anti-atherogenic effects.

 

Study Title: "Effectiveness and safety of a herbal drug containing hawthorn berries and D-camphor in hypotension and orthostatic circulatory disorders/results of a retrospective epidemiologic cohort study" (Link: https://pubmed.ncbi.nlm.nih.gov/11995906/)

Summary: This retrospective epidemiologic cohort study investigated the effectiveness and safety of a herbal drug containing Hawthorn berries and D-camphor in hypotension and orthostatic circulatory disorders. The authors found that the herbal drug was effective in improving symptoms of hypotension and orthostatic circulatory disorders, with no significant adverse effects.

 

Study Title: "The effect of hawthorn (Crataegus oxycantha) extract on cardiovascular risk factors in type 2 diabetes mellitus: a randomized controlled trial" (Link: https://pubmed.ncbi.nlm.nih.gov/22494792/)

Summary: This randomized controlled trial investigated the effects of Hawthorn extract on cardiovascular risk factors in type 2 diabetes mellitus. The authors found that Hawthorn extract supplementation significantly improved blood pressure, lipid profile, and glycemic control in the study participants.

 

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

What studies are there on green coffee bean extract?

Green coffee bean extract (GCBE) is a supplement that is derived from unroasted coffee beans. It is often promoted for its potential health benefits, including its cardioprotective effects. Here are three studies that provide evidence for GCBE's potential cardioprotective properties:

 

Study Title: "Green coffee bean extract improves cardiometabolic parameters and vascular function in obese, hypertensive subjects" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943088/)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of GCBE supplementation on cardiometabolic parameters and vascular function in obese, hypertensive subjects. The authors found that GCBE supplementation improved several markers of cardiovascular health, including blood pressure, endothelial function, and oxidative stress.

 

Study Title: "Green coffee extract supplementation improves cardiovascular risk biomarkers in obese women" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082221/)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of GCBE supplementation on cardiovascular risk biomarkers in obese women. The authors found that GCBE supplementation improved several markers of cardiovascular health, including blood pressure, lipid profile, and inflammatory markers.

 

Study Title: "Effect of green coffee extract on cardiovascular health: evidence from preclinical and clinical studies" (Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647072/)

Summary: This review article provides an overview of the preclinical and clinical evidence supporting the cardioprotective effects of GCBE. The authors discuss the various mechanisms by which GCBE may improve cardiovascular health, including its antioxidant and anti-inflammatory properties, as well as its ability to improve lipid metabolism and blood pressure regulation. They also highlight several clinical studies that have reported improvements in cardiovascular risk factors with GCBE supplementation.

 

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

What studies have been done on Vitamin D and nitric oxide?

Study Title: "Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels" (Link: https://pubmed.ncbi.nlm.nih.gov/22923665/)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of Vitamin D supplementation on endothelial function in patients with Type 2 diabetes mellitus and low Vitamin D levels. The authors found that Vitamin D supplementation improved endothelial function, as measured by flow-mediated dilation, which is related to increased nitric oxide production.

 

Study Title: "Vitamin D and endothelial function" (Link: https://pubmed.ncbi.nlm.nih.gov/24413322/)

Summary: This review article discusses the potential role of Vitamin D in improving endothelial function, which is mediated in part by increased nitric oxide production. The authors highlight the various mechanisms by which Vitamin D can influence nitric oxide production and improve endothelial function, including through regulation of gene expression and calcium homeostasis.

 

Study Title: "Vitamin D deficiency and risk of cardiovascular disease" (Link: https://pubmed.ncbi.nlm.nih.gov/28578227/)

Summary: This review article discusses the potential link between Vitamin D deficiency and increased risk of cardiovascular disease. The authors highlight the various ways in which Vitamin D can influence cardiovascular health, including its role in improving endothelial function and nitric oxide production. They also discuss the potential mechanisms by which Vitamin D deficiency can contribute to cardiovascular disease, such as through increased inflammation and oxidative stress.

 

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

What studies have been done on Vitamin E and nitric oxide?

Study Title: "Vitamin E enhances endothelial nitric oxide synthase activity in endothelial cells" (Link: https://www.ncbi.nlm.nih.gov/pubmed/9856938)

Summary: This study investigated the effect of vitamin E on endothelial nitric oxide synthase (eNOS) activity in endothelial cells. The authors found that treatment with vitamin E increased eNOS activity and nitric oxide production, suggesting that vitamin E may enhance endothelial function by promoting nitric oxide production.

 

Study Title: "Vitamin E supplementation improves endothelial function in type 1 diabetes mellitus: a randomized, placebo-controlled study" (Link: https://www.ncbi.nlm.nih.gov/pubmed/19109500)

Summary: This randomized, placebo-controlled study investigated the effect of vitamin E supplementation on endothelial function in patients with type 1 diabetes mellitus. The authors found that vitamin E supplementation improved endothelial function, as measured by flow-mediated dilation of the brachial artery, suggesting that vitamin E may help to improve nitric oxide bioavailability and promote cardiovascular health in patients with diabetes.

 

Study Title: "Vitamin E and nitric oxide in pre-eclampsia: another example of endothelial dysfunction?" (Link: https://www.ncbi.nlm.nih.gov/pubmed/11466662)

Summary: This study investigated the relationship between vitamin E and nitric oxide in women with pre-eclampsia, a condition characterized by endothelial dysfunction. The authors found that women with pre-eclampsia had lower levels of nitric oxide and vitamin E compared to healthy controls, suggesting that vitamin E may play a role in promoting nitric oxide production and endothelial function in this population.

 

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

What do studies say about grape seed extract?

Grape seed extract (GSE) is a dietary supplement that is often promoted for its potential health benefits, including its cardioprotective effects. Here are three studies that provide evidence for GSE's potential heart health benefits:

 

Study Title: "Grape seed extract reduces blood pressure in hypertensive subjects" (Link: https://www.ncbi.nlm.nih.gov/pubmed/15640470)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of GSE supplementation on blood pressure in hypertensive subjects. The authors found that GSE supplementation significantly reduced systolic blood pressure compared to placebo, suggesting that GSE may have antihypertensive effects and may help to improve cardiovascular health.

 

Study Title: "Effects of grape seed extract consumption on platelet function and blood pressure in hypertensive subjects" (Link: https://www.ncbi.nlm.nih.gov/pubmed/24334460)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of GSE supplementation on platelet function and blood pressure in hypertensive subjects. The authors found that GSE supplementation improved platelet function and reduced systolic blood pressure compared to placebo, suggesting that GSE may have beneficial effects on both hemostasis and cardiovascular health.

 

Study Title: "Grape seed extract supplementation attenuates the adverse effects of high-fat diet on endothelial function in rats" (Link: https://www.ncbi.nlm.nih.gov/pubmed/19284627)

Summary: This animal study investigated the effects of GSE supplementation on endothelial function in rats fed a high-fat diet. The authors found that GSE supplementation improved endothelial function, as measured by aortic relaxation responses, and reduced oxidative stress and inflammation in the aorta, suggesting that GSE may have cardioprotective effects by improving endothelial function and reducing oxidative stress.

 

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

What do studies say about beetroot extract?

Beetroot extract has gained attention for its potential benefits for cardiovascular health, particularly in the context of exercise and blood pressure. Here are five studies that investigate the effects of beetroot extract on blood pressure and exercise:

 

Study Title: "Beetroot juice and exercise: pharmacodynamic and dose-response relationships" (Link: https://www.ncbi.nlm.nih.gov/pubmed/23839191)

Summary: This study investigated the dose-response relationship between beetroot juice supplementation and exercise performance and blood pressure in healthy adults. The authors found that higher doses of beetroot juice led to greater improvements in exercise performance and blood pressure, suggesting that beetroot juice may have potential as an ergogenic aid and blood pressure-lowering agent.

 

Study Title: "Effect of beetroot juice on lowering blood pressure in free-living, disease-free adults: a randomized, placebo-controlled trial" (Link: https://www.ncbi.nlm.nih.gov/pubmed/23473470)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of beetroot juice supplementation on blood pressure in healthy adults. The authors found that beetroot juice supplementation significantly reduced systolic blood pressure compared to placebo, suggesting that beetroot juice may have potential as a dietary intervention for reducing blood pressure.

 

Study Title: "Beetroot juice supplementation improves high-intensity intermittent type exercise performance in trained soccer players" (Link: https://www.ncbi.nlm.nih.gov/pubmed/23842842)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of beetroot juice supplementation on high-intensity intermittent exercise performance in trained soccer players. The authors found that beetroot juice supplementation improved exercise performance and reduced perceived exertion compared to placebo, suggesting that beetroot juice may have potential as an ergogenic aid for athletes.

 

Study Title: "Acute effect of a high nitrate diet on brain perfusion in older adults" (Link: https://www.ncbi.nlm.nih.gov/pubmed/25459980)

Summary: This study investigated the effects of a high-nitrate diet, which included beetroot juice, on brain perfusion in older adults. The authors found that the high-nitrate diet improved cerebral blood flow in several regions of the brain, suggesting that beetroot juice may have potential as a dietary intervention for promoting brain health.

 

Study Title: "Acute beetroot juice supplementation on sympathetic nerve activity: a randomized, double-blind, placebo-controlled proof-of-concept study" (Link: https://www.ncbi.nlm.nih.gov/pubmed/27716697)

Summary: This randomized, double-blind, placebo-controlled trial investigated the effects of beetroot juice supplementation on sympathetic nerve activity in healthy adults. The authors found that beetroot juice supplementation reduced sympathetic nerve activity, which is associated with cardiovascular disease risk, suggesting that beetroot juice may have potential as a dietary intervention for reducing cardiovascular disease risk.

 

*These statements have not been evaluated by the Food and Drug Administration. This product or any product on our website is not intended to diagnose, treat, cure or prevent any disease.

Ultimate Nitric Oxide Nutrition FAQs

What are the side effects of taking Ultimate Nitric Oxide Nutrition?

There are no “side effects” per se. Most people just enjoy the health benefits of increasing their body’s innate power to produce nitric oxide. On very rare occasions, some may initially experience some digestive upset (loose bowels), which typically improves after a few days.

When should I take Ultimate Nitric Oxide Nutrition?

To maximize Ultimate Nitric Oxide Nutrition’s possibilities in activating your body’s innate power to realize optimum health, it is recommended to take Ultimate Nitric Oxide Nutrition separately from meals, at least one hour prior to or following.

Can I take Ultimate Nitric Oxide Nutrition if I am taking prescription medications?

It is always best to check with your doctor before adding something to your daily regimen. Ask your doctor: “Are there any contraindications for these nutrients?” That being said, Ultimate Nitric Oxide Nutrition has motivated wellness through daily use in thousands of individuals.

How much Ultimate Nitric Oxide Nutrition should I take?

The recommended dosage of Ultimate Nitric Oxide Nutrition for activating the body’s innate power to produce nitric oxide is two scoops per day.

How do I know if Ultimate Nitric Oxide Nutrition is working?

Many people will notice that their body is unlocking its innate potential first through better energy and sleep patterns, but the best results are usually seen over time. Allow at least 3-6 months for your body to unlock its full potential.

Where are your l-arginine and l-citrulline sourced from? Do they contain pesticides or heavy metals?

We source our amino acids from a fermentation process conducted in South Korea that uses no heavy metals or pesticides. We also test the finished product for heavy metals and/or pesticides and herbicides (if of plant origin).

I have heard that arginine can trigger herpes (cold sores, etc)?

Some people with herpes may have an outbreak, but the majority do not. If this is a concern for you, you might consider taking 1000 mg of Lysine at a different time than taking Ultimate Nitric Oxide Nutrition as a precaution.

Is Ultimate Nitric Oxide Nutrition safe for Glaucoma?

Please check with your doctor before consuming anything to improve a specific condition. Glaucoma is the leading cause of irreversible blindness in the United States. Research has indicated that nitric oxide may be beneficial for eye health:

“The increase of NO increases vasodilation and improves contractility in the trabecular mesh-work [area that drains fluid from the eye], the final effect being the decrease of intraocular pressure.” – Oftalmologia

NicOx and its partner Bausch & Lomb reported positive top-line results from a mid-stage study of their glaucoma drug candidate. B & L has spent $20 million. “These positive results support the strong potential of our nitric oxide-donating platform in the ophthalmology field.”

Is this product hard on the stomach?

Arginine has been known to be "hard on the stomach". However, Bionox uses arginine alpha-ketoglutarate and has digestive herbal support built in to minimize this tremendously. We have very, very few complaints about it causing digestive upset in our customers.

Is this a 100% natural product and made in the USA?

The product is 100% natural and manufactured in a FDA registered, GMP, US facility. We do Not use artificial sweeteners or colors. It is flavored with berry juices.

How much arginine and citrulline is in Ultimate Nitric Oxide Nutrition?

There are over 5,000 mg of arginine and 2,000 mg of citrulline. The amounts of each are healthy doses and critical to ensuring the longevity of nitric oxide levels.

What is the amount of oxalates in your Nitric Oxide Nutrition per serving? 

All of our products contain zero oxalates. 

Consuming arginine makes my cold sores come back. Is there a method to mitigate the effects of the arginine while still receiving the advantages of your product?

You can take 1000 mg. of lysine at a different time of day than the Ultimate Nitric Oxide Nutrition.

How long to see results for this product?

Energy increase is felt right away by most people. If you take the right dosage (1 scoop in the morning and 1 scoop 12 hours later. Most people see results within a few weeks. The best results are usually seen over time. Allow for at least 3-6 months for your body to unlock its full potential.

Where do the calories come from in M3 Nitric Oxide?

The calories come from the arginine, citrulline, and fruit juice powders.

 

Does UNON contain any amount of sugar? If so, how many grams does it have?

It has no sugar. It is sweetened with Stevia leaf extract.

 

What type of citrulline and arginine does this formula use?

L-Citruline (citrulline by itself, with nothing else attached). L-Arginine AKG (Arginine Alpha Ketoglutarate)

What is Nitric Oxide?

Nitric oxide is a gas molecule that is produced naturally within the body by the conversion of the amino acid L-arginine into nitric oxide by the enzyme nitric oxide synthase. It is a highly reactive molecule involved in various physiological processes within the body.

What will Nitric Oxide do for me?

It can help to lower blood pressure and improve cardiovascular health.

    • Enhanced exercise performance, including improved muscle contraction, reduced inflammation, and increased amino acid delivery to muscles.
    • Enhanced immune function, including the activation and coordination of immune responses, regulation of inflammation, and support for overall immune function and cardiovascular health.
    • Improved brain function, including regulation of blood flow to the brain, enhancement of neurotransmitter release, protection against oxidative stress and inflammation, and support for overall neurological health.
    • Improved sexual function, including regulation of blood flow to sexual organs, enhancement of erectile function in men, and support for sexual arousal and satisfaction in both men and women.

Why do I need  Nitric Oxide?

Nitric Oxide is a molecule produced by nearly every cell in the human body. It is vital to numerous functions such as circulation, digestion, and energy production. is also responsible for intracellular communication, which is essential for cellular processes to be successful. A commonly accepted fact is that nitric oxide production naturally declines as we get older.

What are the "natural flavorings" used in Bionox products derived from?

The constituents of the “natural flavors” are proprietary to protect the intellectual property of Flavor Insights. We can share that only derivatives of the following ingredient categories fit within this scope:

“…a spice, fruit or fruit juice, vegetable or vegetable juice, edible yeast, herb, bark, bud, root, leaf or similar plant material, meat, seafood, poultry, eggs, dairy products, or fermentation products thereof, whose significant function in food is flavoring rather than nutritional.”

This is the FDA defined term for “natural flavors” that can be found in the CFR Title 21.

How does the mechanism of "Extended Release" work in a powder form?

2:1 ratio of arginine to citrulline: L-arginine is a direct precursor to nitric oxide and is readily converted to NO by the enzyme nitric oxide synthase (NOS). However, L-arginine is rapidly metabolized and has a relatively short half-life. L-citrulline, on the other hand, is converted to L-arginine in the body, thus providing a more sustained source of arginine for NO production. The 2:1 ratio ensures that there is an immediate release of NO from the arginine and a more sustained release as the citrulline is converted into arginine.

  1. Vitamins and antioxidants: Some vitamins, such as vitamin C and vitamin E, have antioxidant properties that help protect the NO molecule from being degraded by reactive oxygen species (ROS). By neutralizing these harmful free radicals, antioxidants can help maintain higher levels of NO in the body. Furthermore, certain vitamins, like vitamin D3 and vitamin K2, have been shown to support cardiovascular health, which may indirectly contribute to maintaining optimal NO levels.
  2. Synergistic action of ingredients: The combination of amino acids, vitamins, and antioxidants in Ultimate Nitric Oxide Nutrition works synergistically to support a more prolonged release of NO. While arginine and citrulline provide the raw materials for NO production, the vitamins and antioxidants help protect and maintain the NO molecule, allowing it to exert its vasodilatory effects over an extended period.

Is the xylitol used in your products sourced from birch or corn?

It is certified non-GMO corn.

 

Are the chlorella and cilantro grown in a controlled environment away from outside air?

Yes, both the chlorella and cilantro that we use are grown in a greenhouse.

Will nitric oxide supplements make me jittery?

Nitric oxide (NO) supplements themselves are not known to cause jitteriness. However, some products marketed as NO boosters may contain other ingredients, such as caffeine or stimulants, which can potentially lead to jitteriness or increased alertness. Bionox products don't contain those ingredients.

Why take nitric oxide on an empty stomach?

Taking nitric oxide (NO) supplements on an empty stomach is often recommended for better absorption and efficacy. Here's why:

 

Absorption: When taken on an empty stomach, NO supplements can be absorbed more quickly and efficiently. Without food in the stomach, the supplements can pass through the digestive system more rapidly, allowing for better absorption in the small intestine.

 

Avoiding competition for absorption: Some nutrients and compounds present in food, such as amino acids and dietary proteins, can compete with NO for absorption in the digestive system. By taking NO on an empty stomach, you minimize the potential interference from other substances, ensuring optimal absorption of the supplement.

 

Timing and effectiveness: Nitric oxide supplements are commonly used by athletes and individuals seeking improved exercise performance and increased blood flow. Taking them on an empty stomach, especially before a workout or physical activity, allows for quicker absorption and onset of action, potentially enhancing their effectiveness during exercise.

 

Minimizing digestive discomfort: Some individuals may experience mild digestive discomfort or bloating when taking NO supplements with food. Taking them on an empty stomach reduces the likelihood of these side effects.

 

However, it's important to note that the specific instructions for taking NO supplements may vary depending on the product and the manufacturer's recommendations. It's always advisable to follow the instructions provided on the product packaging or consult with a healthcare professional for personalized advice.

 

Arugula Super Cardio Greens FAQs

What is a superfood? Why are they so important?

A superfood is a nutrient-rich food considered to have a very high nutritional density. This means they provide a lot of nutrients in a small amount of calories. Superfoods are good for you because they are high in vitamin and mineral content to help your body ward off health issues. They promote heart health, weight loss, energy levels, and can reduce the effects of aging when included in diets.

If there is no l-arginine or l-citrulline how is this helping my body make nitric oxide?

Through the nitrate process. Nitrates are found in foods like spinach, arugula, and beets. Unfortunately, many foods lack the nitrate content they should have, so supplementing with products like Arugula Super Cardio Greens has become critical.

How many nitrates are in each serving?

100mg of nitrates per serving.

Is everything in this natural?

Yes, Arugula Super Cardio Greens includes 33 different superfoods, it alkalizes your system, there are naturally occurring vitamins through roots, fruits, spices, and vegetables, and it is naturally sweetened.

Should I take this with Ultimate Nitric Oxide Nutrition?

Yes, you absolutely can take this with Ultimate Nitric Oxide Nutrition. Both products focus on increasing your body's nitric oxide levels, while Arugula Super Cardio Greens gives you your daily dose of vegetables as well! Ultimate Nitric Oxide Nutrition increases your nitric oxide levels through the l-arginine/ l-citrulline method. Arugula Super Cardio Greens uses nitrates found in superfoods like arugula, spinach, and beets that convert to nitric oxide once consumed!

Do you use organic greens? And are they verified?

The goal of Bionox Greens is to boost nitric oxide (NO) by using nitrate-rich ingredients. Unfortunately, most organic sources of these natural sources (arugula, spinach, beets, etc.) are very low in nitrates, so we have to use non-organic ingredients. However, the ingredients we use are extremely nutrient-rich.

Where is the NOX3 green ? 

NOX3 Greens is now known as Arugula Super Cardio Greens; same product, different name.

Are Nitrates Bad for me?

Nitrates are compounds that can be naturally found in many vegetables and benefit human health. When nitrates from vegetables are consumed, they are converted into nitric oxide in the body, which can help to relax blood vessels, lower blood pressure, and improve blood flow. A study published in the American Journal of Clinical Nutrition found that a high-nitrate diet rich in leafy green vegetables was associated with significantly decreasing blood pressure in individuals with hypertension (Kapil et al., 2010).

While there is limited research specifically on the effects of nitrates on immune function, a study published in the Journal of Nutrition found that consumption of a high-nitrate diet improved immune function in older adults (Clifford et al., 2017). The study authors suggested that the beneficial effects may be due to the conversion of nitrates to nitric oxide, which can have anti-inflammatory effects.


On the other hand, nitrates added to processed meats such as bacon, ham, and hot dogs have been shown to increase the risk of certain diseases, including cancer. When nitrates are consumed in large amounts from processed meats, they can be converted into harmful compounds called nitrosamines. Nitrosamines are known to be carcinogenic, meaning they can increase the risk of cancer. A systematic review and meta-analysis published in the International Journal of Cancer found that consuming processed meats was associated with an increased risk of colorectal cancer. The risk increased with higher consumption of processed meats (Chan et al., 2011).

 
In summary, nitrates in vegetables can benefit human health when consumed, while nitrates in processed meats should be consumed cautiously to reduce the risk of harmful health effects.


References:

  • Kapil, V., Khambata, R. S., & Webb, A. J. (2010). The oral nitrate-nitrite pathway in hypertension and cardiovascular disease. American Journal of Clinical Nutrition, 90(3), 785S-788S.
  • Chan, D. S., Lau, R., Aune, D., Vieira, R., Greenwood, D. C., & Kampman, E. (2011). Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. International Journal of Cancer, 128(6), 1411-1423.
  • World Health Organization. (2015). Q&A on the carcinogenicity of the consumption of red meat and processed meat. Retrieved from https://www.who.int/features/qa/cancer-red-meat/en/

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Chelanox FAQs

What ‘heavy metals’ do I need to worry about?

Mercury is one of the most toxic heavy metals in the environment. Other popular heavy metals that are harmful are arsenic, aluminum, and cadmium. These can occur through water pollution, foods, medicines, food containers, and lead-based paints. Bionox uses high-quality, safe, and effective chelating agents that are packed into acid-resistant capsules to bind heavy metals in your body and unwanted minerals and transport them out of the body.

How long until the heavy metals begin to get out of my system?

Results vary for each individual. A couple of weeks is typical. However, it is advised that to do a thorough detox, you would want to use Chelanox for many months to get the desired results.

Is this safe for pregnant women?

It is important to talk with your physician before taking any dietary supplement.

Is this safe to take with other supplements?

It is recommended to take a mineral-dietary supplement in the morning with meals while using this product for proper mineral replacement.

Does this only flush toxins? Is there anything in it that binds toxins?

Modified citrus pectin, chlorella, and zeolites are binders.

Does Chelanox potentially draw mercury out of existing amalgam fillings? I know chelation therapy is not recommended until all mercury fillings are removed.

Chelanox pulls metals out of tissues but not out of the fillings themselves. For this reason, many practitioners recommend chelation therapy despite their patients having amalgam fillings.

Can I begin this detox if I have a metal screw in my wrist?

Always check with your health care provider before starting any new health program. That being said, there is no evidence that taking the ingredients found in Chelanox would be contraindicated for someone who has metal screw implants.

I've been wanting to do a detox. Is this chelation considered a detox? How do I take this?

Chelanox supports and detoxifies all organs and internal systems, including the heart, liver, kidneys, and immune system.

For those with severe health challenges, we suggest taking the recommended dosage of 2 to 3 capsules up to four times daily for several months. Some might do an annual cleanse, take the recommended dose for 1-3 months, and then stop. Others take it daily to eliminate toxins they come in contact with safely.

It is recommended to take a mineral-dietary supplement in the morning with meals while using this product for proper mineral replacement.

Beetroot Energy FAQs

Can I take more than two Beetroot Energy Tarts a day?

Depending on the health benefits you are looking to achieve, you can take 1-3 tarts per serving.

What is the maximum number of Beetroot Energy Tarts I can consume in a day? 

You can take 1-3 lozenges twice per day.

Can I chew the Beetroot Energy tart or does it only work if it dissolves?

You can chew the lozenge. However, it was designed to be dissolved to allow the saliva ample time to interact and break down the nitrates into nitric oxide.

Why use beetroot energy if arugula is a better superfood?

Arugula is higher in dietary nitrates than any other superfood. However, we like to facilitate options. Some people may not like arugula but do like beets. So, we make both Beetroot Energy and Arugula Super Cardio Greens with 100 mg of nitrates per serving.

How does Beetroot Energy help me with cellular energy? 

Cellular energy is important for overall health. If your cellular energy is high, your energy is high.

What distinguishes Beetroot Energy from Arugula Super Cardio Greens?

Arugula Super Cardio Greens is a powder with 26 different superfoods, including the recent addition of arugula. Arugula gives you 100 mg of nitrates per serving. Beetroot Energy is just a few ingredients, such as beets, that also give you 100 mg of nitrates per serving. So it is up to you which one you want to take—or both!

Are all the ingredients in Beetroot Energy natural?

Yes, all the ingredients are natural.

Is it safe to take both Beetroot Energy and Arugula Super Cardio Greens?

It is completely safe to take Beetroot Energy and Arugula Super Cardio Greens. My favorite way to take them together is to take a scoop of Greens and then take a Beetroot Energy tart!

Why does Beetroot Energy have nitrates? I thought nitrates were bad for you.

Things like beets, spinach, arugula, and other greens have naturally occurring healthy nitrates. So consuming nitrates in their natural form is a great way to boost your nitric oxide levels.

Can I take Beetroot Energy with other l-arginine and l-citrulline supplements?

You can absolutely take Beetroot Energy and Arugula Super Cardio Greens with Ultimate Nitric Oxide Nutrition or any other l-arginine supplements. The reason is that nitric oxide is facilitated through two different pathways: the l-arginine pathway (through the circulatory system) and the nitrate pathway (through the digestive system).

What foods can I take with Beetroot Energy and when is the best time?

Beetroot Energy can be taken with any meal. The preferable time is somewhere in between meals, maybe 20 minutes prior to or after eating. That way, your body has enough time to break down all of the beneficial ingredients in Beetroot Energy.

What makes Beetroot Energy lozenges superior to chews? 

Most of the chews on the market do not have nitrates. The advantage of a lozenge is that it interacts more with the saliva, which allows the nitrates to break down into nitric oxide. We believe the lozenge is superior to the chew because it dissolves slowly, allowing you to spend more time with your saliva.

Are the NOX3 Beet Lozenges the same as Beet Root Energy? 

Yes, it is the same product with a different name and label.

Can an older person take Beetroot Energy?

It's always good to check with your healthcare professional, but so far they have been safe to take.

Is the Beetroot Energy good for circulation in the whole body?

Yes, it increases vasodilation and blood flow in the whole body.

Are Nitrates Bad for me?

Nitrates are compounds that can be naturally found in many vegetables and benefit human health. When nitrates from vegetables are consumed, they are converted into nitric oxide in the body, which can help to relax blood vessels, lower blood pressure, and improve blood flow. A study published in the American Journal of Clinical Nutrition found that a high-nitrate diet rich in leafy green vegetables was associated with significantly decreasing blood pressure in individuals with hypertension (Kapil et al., 2010).

While there is limited research specifically on the effects of nitrates on immune function, a study published in the Journal of Nutrition found that consumption of a high-nitrate diet improved immune function in older adults (Clifford et al., 2017). The study authors suggested that the beneficial effects may be due to the conversion of nitrates to nitric oxide, which can have anti-inflammatory effects.


On the other hand, nitrates added to processed meats such as bacon, ham, and hot dogs have been shown to increase the risk of certain diseases, including cancer. When nitrates are consumed in large amounts from processed meats, they can be converted into harmful compounds called nitrosamines. Nitrosamines are known to be carcinogenic, meaning they can increase the risk of cancer. A systematic review and meta-analysis published in the International Journal of Cancer found that consuming processed meats was associated with an increased risk of colorectal cancer. The risk increased with higher consumption of processed meats (Chan et al., 2011).

 
In summary, nitrates in vegetables can benefit human health when consumed, while nitrates in processed meats should be consumed cautiously to reduce the risk of harmful health effects.


References:

  • Kapil, V., Khambata, R. S., & Webb, A. J. (2010). The oral nitrate-nitrite pathway in hypertension and cardiovascular disease. American Journal of Clinical Nutrition, 90(3), 785S-788S.
  • Chan, D. S., Lau, R., Aune, D., Vieira, R., Greenwood, D. C., & Kampman, E. (2011). Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. International Journal of Cancer, 128(6), 1411-1423.
  • World Health Organization. (2015). Q&A on the carcinogenicity of the consumption of red meat and processed meat. Retrieved from https://www.who.int/features/qa/cancer-red-meat/en/

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is it okay to take Beetroot Energy if you have high blood pressure?

It is always good to consult with your doctor, although people with high blood pressure have taken it with excellent results.

I need more circulation in my hands and feet. Would it help me?

Beet Root Energy Tarts increases blood flow, so it would be excellent for you.

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